Day: October 18, 2023

Categories : Mental Health Obstetrics & GynaecologyTags : Leave a comment

Study Reveals Great Variability in Pregnant Women’s Body Images

On By ModernMedia
Photo by Anna Hecker on Unsplash

A new study published in the journal BMC Pregnancy and Childbirth has found considerable variability in the ways pregnancy affects women’s perceptions of their own body, including experiences of negative body image.

Negative body image during pregnancy is known to have serious adverse effects on both the mother and baby. Overall, average levels of body image dissatisfaction were found to be similar for pregnant women compared to the general female population, but on an individual basis, the research discovered large differences, both positive and negative.

The study is thought to be the first meta-analysis comparing pregnant and non-pregnant women, and was led by academics from Anglia Ruskin University (ARU) and the University of York.

The researchers initially screened 2017 separate academic studies, before focusing on 17 studies that provided comparable data. In total, the research included 5200 responses from women who were pregnant and 4172 responses from women who were not pregnant.

By synthesising results from multiple studies, the new research found women’s body image dissatisfaction overall was not statistically different during pregnancy compared with when not pregnant. However, when looking at the separate studies that formed part of the meta-analysis, there are significant variations on an individual level.

Body image dissatisfaction in pregnancy is made up of a combination of complex factors related to the positive and negative experiences of each woman, the researchers believe. For some, body image satisfaction will worsen during pregnancy because of ‘feeling fat’, while others describe feeling that their body is out of their control because they are aware their body will change but cannot stop it. Unrealistic portrayals of pregnant women in the media, often edited to remove uneven skin tone and stretch marks, are also believed to contribute to body image dissatisfaction.

Other pregnant women report having improved body positivity compared to when not pregnant, as they no longer compare their body to the ‘thin ideal’. Some say the improvement is because they place less attention on how their body looks and more on its functionality, focusing on the foetus’s health and their maternal role.

Understanding the causes of body image dissatisfaction in pregnant women is important since it can have physical and mental consequences for mother and baby. Many women who display body image dissatisfaction during pregnancy also exhibit depression and anxiety, both postnatally and longer term. This can lead to negative emotional, cognitive, and behavioural outcomes for the child, as well as poor quality mother-infant interactions.

In addition, body image dissatisfaction has been linked with physical illness as the expectant mother may engage in practices such as unhealthy eating, dieting, purging, and fasting. This can have unwanted negative effects on the foetus, such as low birth weight and premature birth.

Lead author Anna Crossland, University of York, said: “Due to the impact that body dissatisfaction can have on the expectant mother and foetus, it is vital to understand how body image dissatisfaction may change on an individual basis when women are pregnant. What our study has found is there is no universal experience during pregnancy, and so we shouldn’t assume how people feel. Pressures about how we look are still felt by some people during pregnancy and it is much more helpful to ask how someone is, rather than commenting on their appearance.”

Co-author Dr Elizabeth Kirk, Senior Lecturer in Psychology at Anglia Ruskin University, said: “Our earlier work found that women who didn’t feel good about their changing bodies in pregnancy reported lower feelings of bonding with their unborn baby. Therefore, it is crucial that we better understand and support women’s body image during pregnancy, to help women on an individual basis.”

Source: Anglia Ruskin University

Categories : Cardiovascular Disease Emergency MedicineTags : Leave a comment

‘Smart’ EEG Lets Paramedics Identify Stroke Type in the Ambulance

On By ModernMedia
Photo by Mat Napo o Unsplash

Scientists in the Netherlands have developed a special EEG cap which can diagnose stroke in the ambulance, allowing the patient to receive appropriate treatment faster. The research is published in the journal Neurology. 

Every year, millions of people worldwide suffer an ischaemic stroke, the most common type of stroke, when a blood clot blocks a blood vessel of the brain, causing a part of the brain to receive no or insufficient blood. Prompt treatment is crucial to prevent permanent disability or death.  

Neurologist Jonathan Coutinho, Technical Physician Wouter Potters and professor of Radiology Henk Marquering, all from Amsterdam UMC, invented the brain-wave cap, which allows an EEG to be carried out in the back of an ambulance. This shows whether there is an ischaemic stroke and whether the blocked cerebral blood vessel is large or small.

This distinction determines the treatment: in case of a small ischaemic stroke, the patient receives a blood thinner, and in case of a large ischaemic stroke, the blood clot must be removed mechanically in a specialised hospital. “When it comes to stroke, time is literally brain. The sooner we start the right treatment, the better the outcome. If the diagnosis is already clear in the ambulance, the patient can be routed directly to the right hospital, which saves valuable time,” says Coutinho. 

Jonathan Coutinho said: “Our research shows that the brain-wave cap can recognise patients with large ischaemic stroke with great accuracy. This is very good news, because the cap can ultimately save lives by routing these patients directly to the right hospital.”

Between 2018 and 2022, the smart brain-wave cap was tested in twelve Dutch ambulances, with data collected from almost 400 patients. The study shows that the brain-wave cap can recognise patients with a large ischaemic stroke with great accuracy. “This study shows that the brain-wave cap performs well in an ambulance setting. For example, with the measurements of the cap, we can distinguish between a large or small ischaemic stroke,” adds Coutinho. 

In order to develop the brain-wave cap into a product and bring it to the market, TrianecT, an Amsterdam UMC, spin-off company was founded in 2022. In addition, a follow-up study (AI-STROKE) is currently ongoing in which even more measurements are collected in order to develop an algorithm for improved recognition of a large ischaemic stroke in the ambulance. The Dutch Heart Foundation has also recognised the importance of this research and has made 4 million euros available for large-scale research into faster treatment of ischaemic stroke.

Source: Amsterdam University Medical Centers

Categories : AntibioticsTags : Leave a comment

Multidrug-resistant E. Coli Can Take Over the Gut

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Photo by CDC on Unsplash

A study published in PLOS Biology reveals that different strains of Escherichia coli can outcompete one another to take over the gut. The researchers found that a particular strain, known as MDR ST131, can readily colonise new hosts, even if those hosts are already have commensal E.coli in their healthy gut.

The international team, led by experts at the University of Birmingham, used a mouse model to help understand why strains of E.coli that live in a healthy gut are rapidly overtaken of when challenged with a multi-drug resistant strain.

Lead author Professor Alan McNally, from the Institute of Microbiology and Infection at the University of Birmingham, commented: “Antibiotic resistance has been hailed as one of the biggest health problems of our time by the World Health Organisation. There are further problems looming unless we get a better understanding of what is happening so that further drug resistance can be halted in its tracks.

“Scientists have long questioned what makes certain types of E. coli successful multi-drug resistant pathogens. It seems that extra-intestinal pathogenic E. coli, which cause urinary tract and bloodstream infections, are particularly successful when it comes to developing resistance and are therefore especially tricky to treat. Our study provides evidence that certain types of E. coli are more prone to develop antibiotic resistance than others.”

According to previous research, multi-drug resistance alone is not sufficient to drive strains to complete dominance. This most recent study demonstrates that regardless of multi-drug resistant status, certain types of E.coli will outcompete others to live in the human gut.

The work was completed in parts. First, both multi-drug resistant and non-resistant gut-dwelling E. coli were found to easily colonise a mammalian gut. In a second part of the study, the multi-drug resistant strain was found to efficiently displace an already established gut-dwelling E. coli from the mouse intestinal tract. The study provided further details to demonstrate that multidrug resistant lineages of extraintestinal E. coli have particular genetic differences that appear to give them a competitive advantage.

Successful strains of E.coli need to be able to spread between individuals or from the environment into individual hosts. The new study demonstrates that a particular strain, known as MDR ST131, can readily colonise new hosts, even if those hosts are already have E. coli in their healthy gut.

Source: EurekAlert!

Categories : GeneticsTags : Leave a comment

Polygenic Risk Scores are not That Useful, Study Finds

On By ModernMedia
Photo by Sangharsh Lohakare on Unsplash

Polygenic risk scores, which estimate a person’s disease risk based on thousands or millions of common genetic variants, perform poorly in screening and prediction of common diseases such as heart disease, according to a new study led by UCL (University College London) researchers. An extremely high number of individuals would need to be screened for each potential intervention, creating a significant burden on healthcare, while producing numerous false positive results.

It has been claimed that polygenic risk scores are set to transform the prediction and prevention of common diseases, with companies already set up to sell polygenic risk score testing services.

The new study, published in BMJ Medicine, examined 926 polygenic risk scores for 310 diseases. It found that, on average, only 11% of individuals who develop disease are identified, while at the same time 5% of people who do not develop the disease test positive. Unaffected people usually outnumber those affected which results in far more false than true positive predictions.

Lead author Professor Aroon Hingorani said: “Strong claims have been made about the potential of polygenic risk scores in medicine, but our study shows that this is not justified.

“We found that, when held to the same standards as employed for other tests in medicine, polygenic risk scores performed poorly for prediction and screening across a range of common diseases.”

For the new study, researchers looked at data available in an open-access database, the Polygenic Score Catalog, to determine what the detection rate and false positive rate of the scores would be if used in screening.

For breast cancer and coronary artery disease, the risk scores identified only 10% and 12% of eventual cases respectively, using a cut-off that resulted in 5% of unaffected individuals testing positive.

The researchers also investigated how polygenic risk scores would perform if used alongside conventional screening methods.

They found that, if used alongside conventional risk factors, several thousand people would need to have a polygenic risk score done to guide statin prescriptions to prevent one additional heart attack or stroke. The researchers noted that using age alone as a guide to statin prescription would be simpler and more effective at preventing heart attacks and strokes without the need for genetic testing.

They also found that adding polygenic risk scores as first stage screening to determine who should be prioritised for mammography would miss most women who later develop breast cancer and generate many false positives, adding to the burden on healthcare systems.

Co-author Professor Sir Nicholas Wald said: “It has been suggested that polygenic risk scores could be introduced early on to help prevent breast cancer and heart disease but, in the examples we looked at, we found that the scores contributed little, if any, health benefit while adding cost and complexity.”

In the paper, the researchers suggest regulation of commercial genetic tests based on polygenic risk scores to “protect the public from unrealistic expectations and already stretched public health systems from becoming overburdened by the management of false positive results”.

The researchers said consumers of commercial polygenic risk score tests should be informed of the detection rate and false positive rate of the polygenic risk scores as well as the absolute risk with and without a polygenic score result so they can better judge whether the test is useful.

Co-author Dr Jasmine Gratton said: “Polygenic risk scores seem attractive because genotyping is now inexpensive, the same for all diseases and is performed only once because a person’s genotype does not change. However, these features are irrelevant if the test is not useful.”

Professor Sir Nick Wald said: “Our results build on evidence that indicates that polygenic risk scores do not have a role in public health screening programmes.”

The researchers said the performance of polygenic risk scores was unlikely to change much as the variants with the strongest effect had already been identified.

Polygenic risk scores should not be confused with genetic testing for certain single gene mutations such as BRCA1 and BRCA2 which have an important role in screening for breast and ovarian cancer.

Discovering variants that are associated with a higher risk of disease is still crucial for drug development, the team emphasised, as the variants encode proteins that can be targeted with drugs that would be useful for everyone regardless of their genetic makeup.

Polygenic risk score testing is also one of the aims of the UK’s nationwide Our Future Health project.

Source: EurekAlert!

Categories : General InterestTags : Leave a comment

Gift of the Givers is on the Ground in Gaza

On By ModernMedia

Imtiaz Sooliman calls for negotiations and compromise. “The only way to solve the problem is to do what is just.”

Haitham Najjar (left) of The Gift of the Givers Foundation helping to distribute water in Gaza. Photo supplied

By Matthew Hirsch for GroundUp

Dr Imtiaz Sooliman, founder of The Gift of the Givers Foundation, has appealed for negotiations, compromise and peace in the Middle East. The respected South African aid organisation has had a presence in Gaza for nine years.

Gift of the Givers doesn’t have an office in Gaza. Instead, the team of three people moves around distributing medical supplies, food and water. They are also involved in a women and child care centre, a health facility, and schools.

Sooliman says the organisation wants to send more people. “We are preparing to send medical teams but only if it’s not any risk to them.” He says a ceasefire or safe corridor is needed before the teams can enter Gaza. The organisation has 40 medical personnel ready to go in, Sooliman told GroundUp.

On Sunday Gift of the Givers reported that the team has been under severe physical and mental stress.

In 2014 Israel attacked Gaza for seven weeks. Sooliman said his team is reporting that this time it’s completely different. “They said it’s so difficult to move around. There’s so much anxiety and so much fear. The amount of bombs being dropped has never happened before.”

On Tuesday the UN High Commissioner for Human Rights said that 4200 people have been killed, and over one million people displaced, in just ten days, while large areas of the Gaza strip have been reduced to rubble.

The death toll includes a large number of women and children, as well as at least 11 Palestinian journalists, 28 medical staff and 14 UN workers. It also includes over 1300 Israelis, mostly civilians, killed by Hamas on 7 October.

Sooliman said that Gaza’s people face challenges with access to food and water. “Because there’s no electricity, the sewage plants don’t work. Because they can’t do burials, the decomposed bodies are going to cause infections. Because hospitals don’t have antibiotics, there’s a threat of infection there.

“They managed to do some mass funerals yesterday. As the bodies are coming in they are doing it straight away. There are thousands of bodies lying under the rubble that they can’t reach. They don’t have the equipment, they don’t have the personnel, but above all, it’s bloody dangerous to get there,” said Sooliman.

Sooliman said that he had a meeting with the Egyptian ambassador and South Africa’s Foreign Affairs Department on Monday in an attempt to get a humanitarian aid corridor open. “We are also looking at flying supplies on a cargo plane from South Africa and sending trucks to the border in Cairo.”

Asked how this situation compared to other humanitarian relief efforts the organisation had been involved in, Sooliman responded: “This is the worst situation in the world because there is no exit route. You can’t get out. The area is so small. It’s so easy to bomb it … Nobody can have a safety plan. Where are you going to hide? There’s no such thing as safety in Gaza.”

Gaza is only 350km2. It could fit into Cape Town nearly seven times, yet it has half Cape Town’s population.

Sooliman described Israel’s call to evacuate more than one million people from the north to the south of Gaza as “quite ludicrous”. “How can you move 1 million people in 24 hours when there’s no fuel and no cars? Where are you going to go to? Everything is bombed. How do you move an intensive care unit patient?”

He also called for restraint from both sides. “Civilians cannot be attacked in a war and that applies to both sides … At the end of the day, both sides must remember that there is no winner in war. Everybody loses out. The only way to solve this problem in the Middle East is to make peace, act rationally and make compromises.”

“This is not a thing about Jews against Muslims; it’s human against human. It’s not a religious thing, it’s a human thing … it’s about humanity. It’s in the interests of all parties to make compromises. The only way to solve the problem is to do what is just,” he stressed.

“When you act justly you will have peace, prosperity and peace in the entire region. Nobody loses out. Actually everybody gains more. They should go to the negotiating table, make compromises and give a just solution. If you do that then we never have to send any more supplies to the Middle East again,“ Sooliman added.

He said Gift of the Givers were accepting donations for their work in Gaza.

Republished from GroundUp under a Creative Commons Attribution-NoDerivatives 4.0 International License.

Source: GroundUp