Day: May 30, 2023

Categories : Cardiovascular Disease ExerciseTags : Leave a comment

Strong Legs Reduce Risk of Heart Failure after Heart Attack

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Photo by Henry Xu on Unsplash

People with strong legs are less likely to develop heart failure after a heart attack, according to new research. Myocardial infarction is the most common cause of heart failure, with around 6–9% of heart attack patients going on to develop the condition. Previous research has shown that having strong quadriceps is associated with a lower risk of death in patients with coronary artery disease.

Presented at Heart Failure 2023, a scientific congress of the European Society of Cardiology (ESC), this study tested the hypothesis that leg strength is associated with a lower risk of developing heart failure after acute myocardial infarction. The study included 932 patients hospitalised in 2007 to 2020 with acute myocardial infarction who did not have heart failure prior to the admission and did not develop heart failure complications during their hospital stay. The median age was 66 years and 753 participants (81%) were men.

Maximal quadriceps strength was measured as an indicator of leg strength. Patients sat on a chair and contracted the quadriceps muscles as hard as possible for five seconds. A handheld dynamometer attached to the ankle recorded the maximum value in kg. The measurement was performed on each leg and the researchers used the average of both values. Strength was expressed relative to body weight, meaning that quadriceps strength in kg was divided by body weight in kg and multiplied by 100 for a % body weight value. Patients were classified as ‘high’ or ‘low’ strength according to whether their value was above or below the median for their se

The median value for women was 33% body weight and the median value for men was 52% body weight. A total of 451 patients had low quadriceps strength and 481 had high strength. During an average follow-up of 4.5 years, 67 patients (7.2%) developed heart failure. The incidence of heart failure was 10.2 per 1000 person-years in patients with high quadriceps strength and 22.9 per 1000 person-years in those with low strength.

The researchers analysed the association between quadriceps strength (low vs. high) and the risk of developing heart failure. The analysis was adjusted for factors known to be associated with the development of heart failure after myocardial infarction including age, sex, body mass index, prior myocardial infarction or angina pectoris, diabetes, atrial fibrillation, chronic obstructive pulmonary disease, peripheral arterial disease and kidney function. Compared with low quadriceps strength, a high strength level was associated with a 41% lower risk of developing heart failure (hazard ratio [HR]: 0.59; 95% confidence interval [CI] 0.35–1.00; p=0.048).

The investigators also analysed the association between quadriceps strength as a continuous variable and the risk of developing heart failure. Each 5% body weight increment in quadriceps strength was associated with an 11% lower likelihood of heart failure (HR 0.89; 95% CI 0.81–0.98; p=0.014).

Study author Mr. Kensuke Ueno, a physical therapist at the Kitasato University Graduate School of Medical Sciences, Sagamihara, Japan said: “Quadriceps strength is easy and simple to measure accurately in clinical practice. Our study indicates that quadriceps strength could help to identify patients at a higher risk of developing heart failure after myocardial infarction who could then receive more intense surveillance. The findings need to be replicated in other studies, but they do suggest that strength training involving the quadriceps muscles should be recommended for patients who have experienced a heart attack to prevent heart failure.”

Source: European Society of Cardiology

Categories : Cancer Environmental EffectsTags : Leave a comment

Plants can Remove Carcinogenic Compounds from the Air

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Photo by Annie Spratt on Unsplash

Those pot plants in GPs’ waiting room may have an additional health benefit in addition to sprucing the place up. A ground-breaking study has revealed that plants can efficiently remove toxic gasoline fumes, including cancer causing compounds such as benzene, from indoor air.

The study was led by University of Technology Sydney (UTS) bioremediation researcher Associate Professor Fraser Torpy, in partnership with leading Australian plantscaping solutions company Ambius.

The researchers found that the Ambius small green wall, containing a mix of indoor plants, was highly effective at removing harmful, cancer-causing pollutants, with 97 per cent of the most toxic compounds removed from the surrounding air in just eight hours.

Poor indoor air quality is responsible for 6.7 million premature deaths globally, according to the World Health Organisation. Most people spend 90% of their time indoors at home, school or the workplace, so adopting new strategies to improve air quality is critical.

Ambius General Manager Johan Hodgson said the research presented new evidence into the critical role played by indoor plants and green walls in cleaning the air we breathe quickly and sustainably.

“We know that indoor air quality is often significantly more polluted than outdoor air, which in turn impacts mental and physical health. But the great news is this study has shown that something as simple as having plants indoors can make a huge difference,” Mr Hodgson said.

Previous studies on indoor plants have shown they can remove a broad range of indoor air contaminants, however this is the first study into the ability of plants to clean up gasoline vapors, which are one of the largest sources of toxic compounds in buildings worldwide.

Offices and residential apartment buildings often connect directly to parking garages, either by doors or elevator shafts, making it difficult to avoid harmful gasoline-related compounds seeping into work and residential areas. Many buildings are also exposed to gasoline fumes from nearby roads and highways.

Breathing gasoline fumes can lead to lung irritation, headaches and nausea, and has been linked to an increased risk of cancer, asthma and other chronic diseases from longer term exposure, contributing to decreased life expectancy.

Associate Professor Torpy said the study results, based on measurements from a sealed chamber, had far exceeded their expectations when it came to removing gasoline pollutants from the air.

“This is the first time plants have been tested for their ability to remove gasoline-related compounds, and the results are astounding.

“Not only can plants remove the majority of pollutants from the air in a matter of hours, they remove the most harmful gasoline-related pollutants from the air most efficiently, for example, known carcinogen benzene is digested at a faster rate than less harmful substances, like alcohols.

“We also found that the more concentrated the toxins in the air, the faster and more effective the plants became at removing the toxins, showing that plants adapt to the conditions they’re growing in,” Associate Professor Torpy said.

Mr Hodgson said the findings confirmed feedback they’d received after installing plants in hundreds of office buildings across the nation.

“At Ambius, we see over and over again the effects plants have in improving health, wellbeing, productivity and office attendance for the thousands of businesses we work with. This new research proves that plants should not just be seen as ‘nice to have’, but rather a crucial part of every workplace wellness plan.

“The bottom line is that the best, most cost effective and most sustainable way to combat harmful indoor air contaminants in your workplace and home is to introduce plants,” Mr Hodgson said.

Source: University of Technology Sydney

Categories : Genetics Pain ManagementTags : Leave a comment

The Molecular Secrets of the ‘Feel No Pain’ Gene

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The biology underpinning a rare genetic mutation that allows its carrier to feel almost no pain, heal faster and had reduced anxiety and fear, has been uncovered in a new study published in Brain.

Though it may sound like the stuff of superheroes, the carrier of the genetic mutation is an ordinary Scottish woman named Jo Cameron, who was first referred to pain geneticists at University College London in 2013, after her doctor noticed that she experienced no pain after major surgeries on her hip and hand. In 2019, they identified a new gene that they appropriately named FAAH-OUT, which had a rare genetic mutation. In combination with another, more common mutation in FAAH, it was found to be the cause of Jo’s unique characteristics.

The new research describes how the mutation in FAAH-OUT ‘turns down’ FAAH gene expression, as well as the knock-on effects on other molecular pathways linked to wound healing and mood. It is hoped the findings will lead to new drug targets and open up new avenues of research in these areas.

The area of the genome containing FAAH-OUT had previously been assumed to be ‘junk’ DNA that had no function, but it was found to mediate the expression of FAAH, a gene that is part of the endocannabinoid system and that is well-known for its involvement in pain, mood and memory.

In this study, the team from UCL sought to understand how FAAH-OUT works at a molecular level, the first step towards being able to take advantage of this unique biology for applications like drug discovery.

This included a range of approaches, such as CRISPR-Cas9 experiments on cell lines to mimic the effect of the mutation on other genes, as well as analysing the expression of genes to see which were active in molecular pathways involved with pain, mood and healing.

The team observed that FAAH-OUT regulates the expression of FAAH. When it is significantly turned down as a result of the mutation carried by Jo Cameron, FAAHenzyme activity levels are significantly reduced.

Dr Andrei Okorokov (UCL Medicine), a senior author of the study, said: “The FAAH-OUT gene is just one small corner of a vast continent, which this study has begun to map. As well as the molecular basis for painlessness, these explorations have identified molecular pathways affecting wound healing and mood, all influenced by the FAAH-OUT mutation. As scientists it is our duty to explore and I think these findings will have important implications for areas of research such as wound healing, depression and more.”

The authors looked at fibroblasts taken from patients to study the effects of the FAAH-OUT-FAAH axis on other molecular pathways. While the mutations that Jo Cameron carries turn down FAAH, they also found a further 797 genes that were turned up and 348 that were turned down. This included alterations to the WNT pathway that is associated with wound healing, with increased activity in the WNT16 gene that has been previously linked to bone regeneration.

Two other key genes that were altered were BDNF, which has previously been linked to mood regulation and ACKR3, which helps to regulate opioid levels. These gene changes may contribute to Jo Cameron’s low anxiety, fear and painlessness.

Senior study author Professor James Cox said: “The initial discovery of the genetic root of Jo Cameron’s unique phenotype was a eureka moment and hugely exciting, but these current findings are where things really start to get interesting. By understanding precisely what is happening at a molecular level, we can start to understand the biology involved and that opens up possibilities for drug discovery that could one day have far-reaching positive impacts for patients.”

Source: University College London

Categories : Ethics and LawTags : Leave a comment

HPCSA’s Nationwide Crackdown on Bogus Doctors Continues

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Photo by Bill Oxford on Unsplash

The Health Professions Council of SA (HPCSA) has caught out another individual impersonating a doctor. Mr Tshifata Katembwe, a Congolese national, was practising illegally in Kuruman, Northern Cape while not being accredited with the Council, said spokesperson Christopher Tsatsawane.

According to IOL, since January 2022. Mr Katembwe had been working at a medical practice registered under the name of Dr TK Gopane. This was in in contravention of Section 17(1) of the Health Professions Act, 56 of 1974, said Tsatsawane.

The nationwide crackdown on health-care practitioners operating illegally is gaining momentum with arrests made around the country, Health Professions Council of SA (HPCSA) has noted.

Katembwe appeared before the Kuruman Magistrate’s Court last week, and his case was postponed. Meanwhile, Dr Gopane, registered with HPCSA as a medical practitioner, is to be reported to the Medical and Dental Professions Board for appointing an unregistered person and putting unsuspecting members of the public at risk.

In a separate incident, HPCSA announced the arrest of Mr Simba Koromani, an undocumented Zimbabwean national who applied to practise by using the credentials of Dr Lesne Pucjlowski. The doctor notified the HPCSA that someone had tried to apply for a job with her credentials, which led the Council to collaborate with police in tracking down and arresting the fraudster.

Source: IOL

Categories : Healthcare Politics and RegulationsTags : 2 Comments

South African Medical Association Rejects NHI Bill as it Now Stands

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The South African Medical Association (SAMA) issued a statement stating that they reject the current form of the National Health Insurance (NHI) Bill, with a major objection being that the mere establishment of the NHI fund does not embody the Constitutional principle of universal health coverage (UHC).

The NHI Bill is designed to provide one pool of healthcare funding to all South Africans and long term residents.

They state that the NHI Bill was developed without regard to expert concerns and opinions, especially on key issues such as Contracting Units for Primary Healthcare (CUPS), Benefit Packages and Reimbursement Models.

Given the mismanagement of COVID funds by the government and state-owned entities, there is further concern over its ability to regulate the R500bn fund.

SAMA spokesperson Dr Mvuyisi Mzukwa said: “Misappropriation of funds in various state-owned entities casts doubt on government’s ability to handle the health care budgets responsibly. The public, alongside healthcare stakeholders, cannot simply entrust their lives to a government with an established history of financial mismanagement.”

SAMA contends that while the UHC is intended to improve the health and livelihoods of all South African citizens, the Bill as it stands will set the healthcare system up for failure.

“SAMA believes that a robust approach to health systems strengthening is indispensable, as it would rectify the current deficiencies and overcome the challenges posed by the NHI,” the statement concludes. “This approach seeks to enhance the efficiency, effectiveness, and resilience of the healthcare system, ensuring the delivery of optimal care to all individuals. Governance within the healthcare sector must be strengthened, with transparency and accountability at its core. Effective management of funds and meticulous budget allocation is imperative to rebuild trust and demonstrate responsible stewardship of public resources.”