Day: August 24, 2022

Categories : Environmental EffectsTags : Leave a comment

Study Finds Roundup® Weed Killer Causes Convulsions in Animals

On By ModernMedia
Female scientist in laboratory
Photo by Gustavo Fring on Pexels

A recent report by the US Centers for Disease Control and Prevention found more than 80% of urine samples from children and adults in the US contained the herbicide glyphosate. A study published in Scientific Reports takes this research one step further and is the first to link the use of the herbicide Roundup®, a widely used weed killer, to convulsions in animals.

Glyphosate, the weed killer component in Roundup®, is the world’s most commonly used herbicide by volume and by land-area treated. Glyphosate-resistant crops account for almost 80% of transgenic crop cultivated land, which has resulted in an estimated 6.1 billion kg of glyphosate sprayed across the world from 2005 to 2014. Roundup® is used at both industrial and consumer levels, and its use is projected to dramatically increase over the coming years. A major question, yet to be fully understood, is the potential impact of glyphosate on the nervous system.

“It is concerning how little we understand the impact of glyphosate on the nervous system,” said project leader Akshay S. Naraine, a PhD student at FAU and the International Max Planck Research School for Synapses and Circuits. “More evidence is mounting for how prevalent exposure to glyphosate is, so this work hopefully pushes other researchers to expand on these findings and solidify where our concerns should be.”    

Results showed that glyphosate and Roundup® increased seizure-like behaviour in soil-dwelling roundworms and provides significant evidence that glyphosate targets GABA-A receptors. These communication points are essential for locomotion and are heavily involved in regulating sleep and mood in humans. What truly sets this research apart is that it was done at significantly lower levels than recommended by the EPA and those used in past studies. 

“The concentration listed for best results on the Roundup® Super Concentrate label is 0.98% glyphosate, which is about 5 tablespoons of Roundup® in 1 gallon [3.8 litres] of water,” said Naraine. “A significant finding from our study reveals that just 0.002% glyphosate, a difference of about 300 times less herbicide than the lowest concentration recommended for consumer use, had concerning effects on the nervous system.”

Using C. elegans, a soil-dwelling roundworm, researchers first tested glyphosate alone and then both the US and UK formulations of Roundup® from two distinct time periods – before and after the UK’s 2016 ban on polyethoxylated tallowamine (POEAs). These conditions were selected to pinpoint which effects are specific to the active ingredient glyphosate, Roundup® formulations in general, the POEAs surfactants, or any combination of these.   

The study found that the active ingredient glyphosate exacerbated convulsions in C. elegans and suggest the GABA-A receptor as a neurological target for the observed physiological changes. The data also indicate that there is an important distinction between exposure to glyphosate and Roundup®, with Roundup® exposure increasing the percentage of C. elegans that did not recover from seizure activity. The non-recovery phenotype and prolonged convulsions in C. elegans from this study have helped to set a foundation for understanding  nuanced physiological effects of herbicide that occur at concentrations exponentially below neurotoxic levels.

“Given how widespread the use of these products is, we must learn as much as we can about the potential negative impacts that may exist,” said lab head Ken Dawson-Scully, PhD, professor at Nova Southeastern University. “There have been studies done in the past that showed the potential dangers, and our study takes that one step further with some pretty dramatic results.”  

Findings also generate concern over how herbicide use might affect soil-dwelling organisms like C. elegans.

“These roundworms undergo convulsions under thermal stress, and our data strongly implicates glyphosate and Roundup® exposure in exacerbating convulsive effects. This could prove vital as we experience the effects of climate change,” said Naraine.

This study provides evidence to further investigate how chronic exposure and accumulation may lead to neurodegenerative diseases such as Parkinson’s disease. Importantly, there also is a sub-neurodegenerative threshold that may dramatically impact dysregulation of neurotransmission.

“As of now, there is no information for how exposure to glyphosate and Roundup® may affect humans diagnosed with epilepsy or other seizure disorders,” said Dawson-Scully. “Our study indicates that there is significant disruption in locomotion and should prompt further vertebrate studies.”

Source: EurekAlert!

Categories : Mental HealthTags : Leave a comment

Screentime of Parents is a Problem Too

On By ModernMedia
Photo by Tracy le Blanc from Pexels
Photo by Tracy le Blanc from Pexels

Caregivers who consume digital media for relaxation are more likely to engage in negative parenting practices, according to a new multinational study.  The study, published in Computers and Human Behaviour, aimed to investigate the relationship between caregivers’ use of digital media, mental health, and parenting practices at the start of the COVID pandemic. 

On average, caregivers spend three to four hours a day consuming digital media.  

“All members of the family matter when we try to understand families in a society saturated with technology,” said study lead author Jasmine Zhang, a master’s candidate in clinical psychology at Waterloo. “It’s not just children who are often on devices. Parents use digital media for many reasons, and these behaviours can impact their children.” 

To conduct the study, the researchers surveyed 549 participants who are parents of at least two children between the ages of five and 18. Caregivers provided information about their digital use, their own mental health and their children’s, family functioning, and parenting practices.

The researchers found that caregivers with higher levels of distress engage in more screen-based activities and were more likely to turn to devices for relaxation. This consumption was correlated with negative parenting practices such as nagging and yelling. They also found that negative parenting behaviours were more likely when technology interrupted family interactions. The experiment didn’t focus on specific apps or websites that caregivers use but rather found that caregivers who spend time on screens were retreating from being present with their family, which is correlated with negative parenting practices.

Not all media consumption had negative outcomes: keeping in touch digitally was related to lower levels of anxiety and depression and higher levels of positive parenting practices such as listening to their children’s ideas and speaking of the good their children do.  

“When we study how parents use digital media, we need to consider caregivers’ motivations for using devices in addition to how much time they spend on them,” Zhang said. 

Study co-authore Dillon Browne, Canada Research Chair in Child and Family Clinical Psychology and professor of psychology at Waterloo, expects that these patterns will continue after the pandemic.

“The family media landscape continues to grow and become more prominent,” said Prof Browne. “Going forward, it’s important to consider the nuances of digital media as some behaviours are related to well-being, and others are related to distress.” 

The researchers plan further research and hope that their work will yield guidelines for caregivers to manage their screen-based behaviours. 

Source: EurekAlert!

Categories : COVID Metabolic DisordersTags : Leave a comment

Youth-onset Type 2 Diabetes Increased 77% During COVID Pandemic

On By ModernMedia
Photo by Towfiqu Barbhuiya on Unsplash

Published in The Journal of Pediatrics, a study reviewing medical records has found that new diagnoses of type 2 diabetes in children has surged 77% since the pandemic, accelerating a trend that is already a great concern for parents and healthcare professionals.

The new analysis documented the rise in cases with measures of increased body mass index (BMI) and higher blood glucose and haemoglobin A1c test results.

During the first year of the pandemic, medical records showed that more boys (55%) were diagnosed with type 2 diabetes than girls (45%), a reversal of the percentages during the pre-pandemic years.

In addition, during the pre-pandemic years, more patients were diagnosed while outpatients (57%) than during the pandemic year, when more were diagnosed and treated as inpatients (57%), suggesting greater severity.

Overall, the researchers found that 21% of the young people diagnosed presented with “metabolic decompensation,” of which the most serious symptoms include vomiting, lethargy, confusion and rapid breathing. Pre-pandemic, such symptoms occurred in only 9% of children with new-onset type 2 diabetes. Because the study involved a retrospective review of medical records, the investigators say there is a potential for inconsistencies in reporting or missing information.

“It used to be rare to hear about a child with type 2 diabetes, but its prevalence in adolescents has almost doubled in the past 20 years,” said Dr Kesley. “Type 2 diabetes is associated with rapidly progressive disease and early onset of complications and, unfortunately, was on the rise even prior to the COVID pandemic.”

Data suggests diagnoses of type 2 diabetes in children are increasing by 4 to 5% per year. The COVID pandemic introduced multiple challenges and increased attention to children with pre-existing disorders such as diabetes.

“In the spring of 2020 we were inundated with new youth-onset type 2 diabetes cases,” said Dr Kelsey. “We were used to seeing 50-60 new cases per year and that increased to more than 100 new cases in a year. Colleagues at other institutions were seeing the same thing, so we gathered a team of researchers to evaluate the frequency and severity of new cases during the first year of the pandemic compared to the mean of the prior two years. It was challenging because there is not a funded national registry for youth-onset type 2 diabetes, so this work was done with an enormous and voluntary effort of investigators across the country who are dedicated to treating diabetes in youth.

“To our knowledge, this is the first multicentre study to report the impact of the COVID pandemic on rates of newly diagnosed youth onset type 2 diabetes,” Dr Kesley said. “We found that the pandemic was associated with an increase in new type 2 diabetes cases compared to the two prior years, as well as an increase in proportion of youth presenting in metabolic decompensation.”

Contributing factors could be stem from the immense behavioural and environmental changes since the onset of the pandemic. Worldwide, children were enrolled in school virtually, extracurricular activities were limited and daily routines were adjusted to decrease the potential exposure to COVID. Consequences of this included increased screen time, unhealthy eating habits, decreased physical activity and poor sleep habits, which all have associations with increased BMI.

Whether COVID infection was the direct cause for the increase, or just associated with environmental changes and stressors during the pandemic is unclear. “Further studies are needed to determine whether this rise is limited to the United States and whether it will persist over time,” said Dr Kesley. “There is still a lot of work to be done.”

Source: EurekAlert!

Categories : Pain Management Substance UseTags : Leave a comment

Many Medical Cannabis Users also Use Nicotine

On By ModernMedia
Photo by RODNAE Productions from Pexels

Users of medical cannabis are more likely to also use nicotine products than the general population, according to a Rutgers University study published in the American Journal on Addictions.

“Simultaneous use of cannabis and nicotine is a growing concern, but while the relationship between recreational cannabis and nicotine use is well-established, little is known about nicotine use among users of medical cannabis,” said Mary Bridgeman, a clinical professor at Rutgers Ernest Mario School of Pharmacy.

The researchers surveyed 697 patients aged 18–89 at a medical marijuana dispensary on their nicotine and cannabis use, how they self-administered the cannabis (smoked, vaped) and the medical conditions that qualified them for using therapeutic cannabis.

Nearly 40% of medical marijuana users reported using nicotine – sharply higher than the 14% of US adults who smoke.

Therapeutic cannabis users who also used electronic cigarettes or didn’t use nicotine at all were about four times more likely to vape, rather than smoke, cannabis than those who exclusively smoked cigarettes.

The study also found 75% of the respondents smoked cannabis rather than vaped and about 80% of the cigarette smokers reported planning to quit in the next six months.

“These findings reveal that while medical cannabis dispensaries may recommend vaping rather than smoking cannabis due to the health concerns associated with combustible products, this recommendation alone may not influence patients who also smoke cigarettes,” said Professor Marc Steinberg, co-author of the study.

“Between the higher rates of nicotine use in those using medical cannabis, the fact that cigarette smokers opt to smoke cannabis as well and that those people also are seeking to quit using nicotine presents a strong argument that dispensaries provide tobacco control messaging at the point-of-sale to encourage cigarette smokers to quit,” Prof Steinberg added. “The strategy also could increase the chances that a medical cannabis user would vape the product, which is a less harmful route than smoking.”

Source: Rutgers University

Categories : Expert Opinion HospitalsTags : Leave a comment

Proper Handwash Basin Design and Use is Critical to Controlling AMR

On By ModernMedia
Photo by Piron Guillaume on Unsplash

Some 10 million people annually are projected to die annually from antimicrobial resistance AMR in 2050, says Briëtte Du Toit, Programme Manager and Training Coordinator at Infection Control Africa Network (ICAN). While efforts to develop new antibiotics and conserve current ones are under way, it is vitally important to limit hospital-acquired infections as this is where many resistant strains spread. One of the key ways of controlling this is through the proper use of handwash basins, which necessitates a collaboration between the medical and engineering disciplines.

Presenting at the 14th SAFHE Southern African Healthcare, Du Toit stressed the importance of proper handwashing protocol and the critical importance of handwash basin design and placement to control the spread of hospital-acquired infections amid rising antimicrobial resistance.

The simple protocol of hand washing is perhaps one of the most important in modern medicine. In the past, clinicians might perform and autopsy and then deliver a child, all without washing their hands. It was only until the mid 1800s when Hungarian doctor Ignaz Semmelweis discovered the importance of hand washing, causing infection rates to plummet after the introduction of this most simple of protocols.

In modern hospitals, handwash basin design and placement, along with inadequate water supply and inadequate knowledge on the part of staff, contributes to inadequate hand washing and therefore high infection rates, Du Toit pointed out.

The design of handwash basins may seem straightforward, but there are many factors to consider. Water may drop onto other surfaces, or splash onto HCWs’ clothes. If medical supplies are stored nearby, then stray water droplets may also land on them.

A study of handwash basins showed that only 23% of basins were used for handwashing, while the remainder were used for a variety of activities including waste disposal. Of the basins used for waste disposal, 55% were contaminated. Another study showed that, in the ICU setting, washbasins were used for handwashing a mere 4% of the time. A sluice is also needed in close proximity to patients, otherwise staff will use handwash basins for incorrect disposal of body fluids.

Having the outlet directly beneath the tap as in a traditional domestic basin increases contamination. A bowl depth less than 19cm also contributed to contamination. Without a bowl cover, 9% of gowns and 6% of hands were found to be contaminated with gram-negative bacili (GNB), versus 2% of gowns and 0% of hands when a cover was present.

Significant improvements were also seen in ‘water-free’ protocols at the point of care, which involved the extensive use of disposable wipes, bottled water and practices such as using electric shaving. The implementation of water-free protocols at one hospital saw a drop in GNB colonisations from 26.3 to 21.6 / 1 000 ICU admission days. An even greater effect was seen for long-term ICU stays, with a 3.6 fold-reduction for stay exceeding 14 days.

Du Toit concluded by stressing the importance of collaboration between the medical and engineering fields, sharing data. Engineers should also be on IPC committees. Likewise, medical personnel should be part of the project team during building and renovations.