A new study from Tel Aviv University reveals that solar exposure increases appetite in males – but not in females. It is the first gender-dependent medical study ever conducted on UV exposure, and reveals a molecular connection between UV exposure and appetite.
Skin as a regulator of appetite
The groundbreaking study was led by Prof. Carmit Levy and PhD student Shivang Parikh and published in Nature Metabolism.
The study was based on epidemiological data collected in a year-long survey about the eating habits of approximately 3000 Israelis of both sexes, including self-reports from students who had spent time in the sun, combined with the results of a genetic study in a lab model. The findings identify the skin as a primary regulator of metabolism in both lab models and humans, influencing appetite.
In females, oestrogen blocks appetite after sun exposure
The study unravels the differences between males and females in the activation of the metabolic mechanism. The researchers explain that in males of both animal species and humans, sun exposure activates a protein called p53, to repair any DNA damage in the skin that might have been caused by the exposure. The activation of p53 signals the body to produce a hormone called ghrelin, which stimulates the appetite.
In females, oestrogen blocks the interaction between p53 and ghrelin, and consequently does not catalyse the urge to eat following exposure to the sun.
Males and females, have differences in metabolism which impacts both their health and their behaviour. However, so far it has not been established whether the two sexes respond differently to environmental triggers such as exposures to the sun’s UV radiation.
“We examined the differences between men and women after sun exposure and found that men eat more than women because their appetite has increased. Our study was the first gender-dependent medical study ever conducted on UV exposure, and for the first time, the molecular connection between UV exposure and appetite was deciphered. Gender-dependent medical studies are particularly complex, since twice the number of participants is required to find statistically significant differences,” explained Prof Levy.
“As humans, we have cast off our fur and consequently, our skin, the largest organ in our body, is exposed to signals from the environment. The protein p53, found in the skin, repairs damage to the DNA caused by sun exposure, but it does more than that. It signals to our bodies that winter is over, and we are out in the sun, possibly in preparation for the mating season. Our results provide an encouraging basis for more research, on both human metabolism and potential UV-based therapies for metabolic diseases and appetite disorders,” Prof Levy concluded.
Source: Tel Aviv University
