Day: March 4, 2022

Categories : Diseases, Syndromes and ConditionsTags :

Paracetamol May Protect Against Kidney Damage in Malaria

On By ModernMedia
Anatomic model of a kidney
Photo by Robina Weermeijer on Unsplash

Paracetamol may help protect against kidney damage in patients with malaria, according to a study recently published in Clinical Infectious Diseases.

The study found that for patients with severe malaria caused by the malaria parasite Plasmodium knowlesi (the most common cause of malaria in Malaysia), taking paracetamol regularly for 3 days led to improvements in kidney function when tested one week later.

The findings are important because they will help provide the best possible treatment to patients with severe malaria, said study leader Dr Daniel Cooper.

“Even minor kidney injury can have long-term effects, so anything we can do to minimise kidney injury from malaria will be beneficial for these patients’ long-term outcomes,” Dr Cooper said.

In collaboration with international partners, the study involved 396 people with knowlesi malaria in Sabah, Malaysia.

Assistant Professor Bridget Barber said that in severe malaria, red blood cells can rupture, releasing haemoglobin which can have a toxic impact on kidneys, and it is now believed that paracetamol can help to mitigate these toxic effects.

“These results are consistent with other studies conducted in patients with other forms of malaria, including in adults in Bangladesh, and in children in Africa. Importantly, these findings also suggest that paracetamol may help to protect the kidneys in other conditions that are also associated with rupture of red blood cells,” A/Prof Barber said.

Source: MedicalXpress

Categories : DentistryTags :

Nocturnal Teeth Grinding is Damaging for Temporomandibular Joints

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Woman showing her teeth
Photo by Maria Lysenko on Unsplash

Sleep bruxism, nocturnal teeth grinding and clenching of the upper and lower jaw, can have a number of health impacts. A new study published in the Journal of Advanced Research found that certain tooth shapes and tooth locations could well lead to temporomandibular joint problems as a result of bruxism.

About 15% of the population grind their teeth while they are asleep, a condition which is more common among younger people. The\ pressure exerted on tooth surfaces and on the jaws can be immense and is thought to cause various dental health problems. It can also result in pain in the jaw muscles and headaches. Specific combinations of tooth shape and tooth location during grinding are theorised to have an influence on the mechanical load on the temporomandibular joint and can thus be considered a risk factor for temporomandibular joint (TMJ) disorders.

To investigate whether sleep bruxism has a negative impact on the TMJ structures, researchers used a state-of-the-art computer model of the masticatory region, which includes bone, cartilage and muscular structures. Such computer models can be used to investigate research questions when direct studies on patients are not feasible on ethical grounds.

The study investigated two factors thought to be involved: tooth shape and location, The study simulated the effects of lateral grinding on the first molar and on the canine with six different wear facet inclinations, resulting in a total of twelve simulated scenarios.

“Our results show that both the inclination and location of the wear facets have an influence on the strength of the mechanical load on the temporomandibular joint,” explained study leader Benedikt Sagl. “However, it would appear that the decisive factor is the steepness of the grinding facet. The flatter the tooth, the higher the loading on the joint and therefore the higher the risk of a TMJ disorder.” Conversely, if the dental cusps involved in bruxism have a steeper angle of inclination, the calculated joint loading was lower, even with the same “grinding force” (bruxing force). Further research, coupled with clinical investigations, will seek to establish whether this finding can be incorporated into the development of therapeutic interventions for sleep bruxism.

Source: Medical University of Vienna

Categories : Diseases, Syndromes and ConditionsTags :

Candida Glabrata Genome Yields Secrets of Virulence and Drug Resistance

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Genetics
Source: Pixabay

A project sequencing the Candida glabrata genome has revealed insights into the pathogenic fungus’s virulence and resistance, which researchers found to have been enhanced by transmission through humans as they travel between continents. The project’s findings appear in Genetics. 

C. glabrata is an opportunistic human fungal pathogen that causes superficial mucosal and life-threatening bloodstream infections in individuals with a compromised immune system. It most commonly affects the urinary tract, genitals, mouth, and the bloodstream. If it is not caught, these infections can become deadly.  It is also very resistant to certain antifungal drugs, so understanding why resistance occurs is key to knowing how to treat it effectively. 

Using samples from eight hospitals in Scotland to sequence the genome of C. glabrata, new insights on the species were made. This includes information on how it reproduces and its genetic diversity. Genes increasing its infectivity also confer an advantage for survival, and the drug-resistance genes often evolve within patients.

These findings provide scientists with an advantage in treating fungus, allowing research to focus in ways that were not possible before. It also helps aid understanding on how the pathogen spreads, which is important to identifying infections.

Dr Rhys Farrer, one of the Principal Investigators at the MRC Centre for Medical Mycology at the University of Exeter, said: “Our study sheds new light on the genetic diversity of Candida glabrata. We have demonstrated that this deadly human fungal pathogen is being spread between continents, probably by humans, and recombining to form new populations, which is likely contributing to its high virulence and increasing drug resistance.”

Source: University of Exeter