Day: November 21, 2020

Tinnitus reduced by electric stimulation of Tongue

Science reports that a serendipitous discovery by Hubert Lim, a biomedical engineer at the University of Minnesota has led to a new treatment of tinnitus: using electrical shocks in other parts of the body.

It’s “really important” work, says Christopher Cederroth, a neurobiologist at the University of Nottingham, University Park, who was not involved with the study. The finding, he says, joins other research that has shown “bimodal” stimulation—which uses sound alongside some kind of gentle electrical shock—can help the brain discipline misbehaving neurons.

The experiment involved 326 people with tinnitus receiving electrical shocks to their tongue whilst listening to background noise on headphones.

Over the 12 weeks of treatment, the patients’ tinnitus symptoms improved dramatically. More than 80% of those who complied with the prescribed regimen saw an improvement. And they saw an average drop of about 14 points on a tinnitus severity score of one to 100, the researchers report today in Science Translational Medicine. When the team followed up after 12 months, 80% of the participants still had lower tinnitus scores, with average drops of 12.7 and 14.5 points.

The results are “quite impressive,” Cederroth says. The reduction in symptoms is larger than other studies have found for bimodal stimulation, he says, and it’s the first evidence of such long-term effects. A 2018 paper that stimulated the skin on the neck and cheek over a shorter time improved patients’ tinnitus, but there was a smaller dip in severity scores, he notes, of only about seven points. And cognitive behavioral therapy, a kind of talk therapy that is currently the only clinically validated tinnitus therapy, improves severity scores by about 10 points on average.

Still, University of Oxford neuroscientist Victoria Bajo notes there was no control group in the trial. Without that, she says, it’s impossible to know how much patients would have improved on their own or with a placebo. The work is good, she says, “but this is the beginning.”

Study finds exercise intensity not linked to mortality in older adults

Medical Express reports that a study published in The BMJ with 1567 participants prescribed high intensity interval training (HIIT) or  moderate intensity continuous training (MICT) to older adults, with surprising results.

The researchers found no difference in all cause mortality between the control group (4.7%, 37 participants) and combined HIIT and MICT group (4.5%, 35 participants).

They also found no differences in cardiovascular disease or cancer between the control group and the combined HIIT and MICT group.

For example, the total proportion of participants with cardiovascular disease after five years was 15.6%, with 16% (125 participants) in the control group, 15% (58 participants) in the MICT group, and 15.3% (61 participants) in the HIIT group.

“This study suggests that combined MICT and HIIT has no effect on all cause mortality compared with recommended physical activity levels,” write the researchers.

China in discussion with WHO over possible use of its vaccines worldwide

Despite not having clinical trials not being completed, essential workers in China have been given Chinese-developed vaccines, writes the Daily Maverick. The World Health Organisation (WHO) had reportedly held the first talks aimed at getting the Chinese COVID vaccine. Socorro Escalate, WHO’s coordinator for essential medicines and health technologies in the Western Pacific region, said:

“Potentially through this emergency use listing the quality and safety of these vaccines and efficacy could be assessed. ..and then this could be made available for our licensees.”

The Daily Maverick continues:

China has at least four experimental vaccines in the final stage of clinical trials – two are developed by state-backed China National Biotec Group (CNBG), and the remaining two are from Sinovac Biotech and CanSino Biologics respectively.

They are tested in such countries as Pakistan, Indonesia, Brazil, Russia and the United Arab Emirates.

Last month, the UAE authorized the emergency use of a CNBG vaccine, the first international emergency clearance for one of China’s vaccines, just six weeks after human trials began in the Gulf Arab state.

Philippines President Rodrigo Duterte said last month it would prioritise China and Russia in his country’s global shopping for a vaccine.