Day: November 13, 2020

Elon Musk Says He May Have COVID

Elon Musk, CEO of SpaceX and Tesla tweeted that he may have COVID, according to Bloomberg.

The 49 year old tech entrepreneur said that so far his symptoms resemble those of a cold. He took four rapid antigen tests, which are cheaper and faster but two of them came back as negative and two came back as positive. He commented that these results were “extremely bogus”.

No stranger to courting controversy, Musk has in the past cast doubts about COVID, even claiming in March that there would be “zero” cases in the United States by April (which currently has recorded 153 496 new daily cases as of writing this article). He then appeared to cast further doubts, saying that the number of cases would “explode” due to the number of false positives.

Vaping May Increase Respiratory Disease Risk

Research has increasingly been focused on the health effects of vaping, usually touted as a way to quit combustible smoking, and evidence is accumulating for their risks.

Research by Boston University School of Public Health and School of Medicine has revealed that, far from being harmless, vaping may in fact raise the risk for a number of respiratory diseases by 21% for former e-cigarette users and 43% for current users.

Corresponding author Dr Andrew Stokes, assistant professor of global health at Boston University said, “This provides some of the very first longitudinal evidence on the harms associated with e-cigarette products.

“In recent years we have seen dramatic increase in e-cigarette use among youth and young adults which threatens to reverse decades of hard-fought gains,” Stokes said. “This new evidence also suggests that we may see an increase in respiratory disease as youth and young adults age into midlife, including asthma, COPD, and other respiratory conditions.”

Previous research has largely focused on in vitro studies, or short-term studies with human participants. The study used data from 21 618 participants from the nationally representative Population Assessment of Tobacco and Health (PATH) survey. To isolate the effect of e-cigarettes, the researchers adjusted for any form of combustible smoking use, including second-hand smoking.

“With a longitudinal study design and extensive sensitivity analyses, the study adds to a growing body of evidence indicating long-term health risks of e-cigarette use to the respiratory system,” said study lead author Wubin Xie, a postdoctoral associate at Boston University.

Source: Medical Xpress

Spike Protein Mutation May Be COVID’s Achilles Heel

New research suggests that the very spike protein that makes SARS-CoV-2 so infective may also make it more vulnerable to vaccines. The characteristic “crown” of spikes on the virus gives rise to its “coronavirus” name.

A common mutation in the D614G protein makes a flap open in the spike. This spike makes it easier for the virus to latch onto cells, but this same flap opens a pathway directly into the virus’ core. This makes it easier for antibodies, such as those in the vaccines presently undergoing testing, to infiltrate into the virus, and disable it.

Yoshihiro Kawaoka, a virologist at the University of Wisconsin-Madison, explains: “The original spike protein had a ‘D’ at this position, and it was replaced by a ‘G,’ Several papers had already described that this mutation makes the protein more functional and more efficient at getting into cells.”

This mutation, they found, makes the virus replicate 10 times faster and also makes it more infectious.

When hamsters were exposed to the mutated and unmutated coronavirus strains, the ones infected with the mutated strain were found to transmit the virus much faster than those infected with the unmutated strain. Neither strain seemed to make the hamsters sicker, suggesting that the mutation does not make the virus more lethal. Researchers caution that the animal test results may not hold true for humans, and that constant vigilance in observing and documenting mutations in the SARS-CoV-2 virus is necessary. 

Source: Medical Xpress